Premier League Predictions: Live Odds and 3 Best Bets for Saturday, September 27

Get ready for Saturday's Premier League games by diving into our betting preview. Our soccer insider has 3 best bets on tap for September 27. Good luck!
Premier League Predictions Live Odds and 3 Best Bets for Saturday, September 27
Bruno Fernandes and Manchester United are part of our EPL betting card for Saturday!
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Today, we’ll reveal the opening odds and three bets below for the Premier League matches on Saturday, September 27th. Let’s get into it!

Manchester United (+105) at Brentford (+230) Saturday 7:30 AM - Draw Odds (+270)

Man U is finally coming into this game on the tails of a big win against Chelsea. They have also won 2 of their last 3 and seem to be in good form.

Brentford has just 1 win so far this season and has lost 3 of 5 to start its 2025-26 campaign. Man U has had the upper hand in this matchup, winning 3 of the last 5, with Brentford taking just 1 of those games.

Brighton (+310) at Chelsea (-130) Saturday 10:00 AM - Draw Odds (+290)

Brighton hasn’t gotten off to a great start this season, winning just 1 of their first 5 games this year. They will face an uphill battle this week as well, taking on a solid Chelsea squad on the road.

Chelsea is coming off their first loss of the season last week and will be looking to bounce back to keep momentum high this weekend. Chelsea has an electric offense, and Brighton has struggled on defense, so we may see a lot of goals in this one.

Liverpool (-110) at Crystal Palace (+270) Saturday 10:00 AM - Draw Odds (+270)

Both teams are undefeated in the Premier League so far this year. Liverpool has won all 5 of their games thus far, while Crystal Palace has 2 wins and 3 draws under its belt.

Palace have been very strong on defense, allowing just 2 goals so far this season. However, their defense will be tested this weekend against the favorites to win the Championship this season. This should certainly be a fun one.

Bournemouth (+145) at Leeds (+190) Saturday 10:00 AM - Draw Odds (+225)

Since their week 1 road loss to Liverpool, Bournemouth have been unbeaten, winning 3 of their last 4 games. They now take on a scrappy Leeds team, who has managed 2 wins in their first 5 of the season in their return to the Premier League.

Neither of these teams have been outstanding on offense, but they have been driven by their solid defensive units. Expect a close, but low-scoring game here.

Burnley (+1100) at Manchester City (-650) Saturday 10:00 AM - Draw Odds (+650)

There isn’t much to say about this one. Man City is the far superior team in this match. While they haven’t gotten off to an amazing start, sitting at 2-2-1, they have an upper hand being at home against a lesser opponent. I think Man City gets some confidence this weekend.

Sunderland (+340) at Nottingham Forest (-120) Saturday 12:30 PM - Draw Odds (+260)

Chelsea is off to a great start, while Man U looks to once again be sputtering. This is always a fun game between two historic squads, but Man U is without a win in this matchup since 2023.

Having the home field may help Man U’s case a bit, but they will need to hold off Chelsea’s offense that has scored 9 goals over their first 4 league games. Both teams to score has hit in 4 of the last 5 games, so that may be something to look for.   

Wolves (+500) at Tottenham (-205) Saturday 3:00 PM - Draw Odds (+350)

Fulham are coming into this game off their first league win of the season over Leeds. Both of these sides have only one win over their first 4 league games, but Fulham has looked much more solid against good competition.

Having the home field will likely help Fulham, but Brentford is a scrappy team. This should be a fun one to close out an exciting Saturday of league play.

Best Bets

Manchester United (+105) at Brentford - Man U is starting to look like a capable team again, winning 3 of their first 5 in this Premier League campaign. Brentford has struggled so far, and I think this is a great line for the Reds.

Liverpool (-110) at Crystal Palace - Liverpool has struggled with Palace in the past, but I think this team is a different animal. Liverpool has looked flawless and has yet to lose a game in any competition this season. I think they will keep the streak alive this weekend.

Bournemouth (+145) at Leeds - Leeds has been surprisingly solid so far in their return to the Premier League; however, Bournemouth has looked great. They are undefeated in their first 5 games, and while Leeds has a solid defense, I’m not sure they'll be able to break through and keep this close.

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