Arsenal is already in the F.A. Cup quarterfinals after its 2-0 win Monday, and three more teams will join the Gunners Tuesday.
The big match has Chelsea hosting Liverpool, but there are also two other intriguing contests.
Reading, which has a habit of playing well in this competition, will host the newest sensation in the Premier League, Sheffield United. West Bromwich Albion, which leads the EFL Championship, will host Newcastle United.
All matches must be settled today, with no replays, so the team to advance bets might be the better way to bet in at least two of the games.
Chelsea (+155) vs. Liverpool (+155), draw (+270), 2:45 p.m. EST (ESPN+)
THE PICK: Liverpool to advance (-120)
Reading (+430) vs. Sheffield United (-152), draw (+280), 3 p.m. EST (ESPN+)
THE PICK: Sheffield United -0.75 (-120)
West Bromwich Albion (+140) vs. Newcastle United (+200), draw (+230), 3 p.m. EST (ESPN+)
THE PICK: West Brom to advance (-118)