Matt Stafford looks to lead the Rams to a defense of their Super Bowl championship.
Matt Stafford looks to lead the Rams to a defense of their Super Bowl championship.@RamsNFL on Twitter

NFL Kickoff: Mims picks season opener, Rams vs Bills; Josh Allen, Cooper Kupp prop bets; over/under, spread

Game time is 8:20 pm EDT.

Thursday Night Football starts with the Los Angeles Ram against the Buffalo Bills. The Rams are the home team. The Bills open the season with the best odds to win the Super Bowl.

The Numbers: Bills are favored by 2.5 points and the total is 52. The Money line is Bills -135 and Rams +115.

Coaching Match Up: Sean McVay with an edge over Sean McDermott. McVay led the Rams to the Super Bowl and they are defending champions.

Injury Report: Van Jefferson, wide receiver is out for the Rams. Jalen Ramsey had off-season surgery but is expected to play. No one is listed on the report for the Bills.

Player Props: Josh Allen over 35.5 yards rushing. In his last 5 games in 2021, Allen averaged 70 yards. The price is -127. Take him over. Cooper Kupp over 90.5 yards receiving. The price is -117. Kupp led the league last year in receiving yardage. Take him over.

The Action: 59% of the action is on the Bills.

The Selection: The Bills are an excellent football team. Top 5 on offense and defense. Rams have never lost a season opener under McVay. Buffalo will have a rookie cornerback starting in the secondary. Matthew Stafford will exploit that. Rams win and cover. Game goes under the 52.

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