Week 4 College Football Betting Guide: 3 Best Bets for Saturday, September 21

Our college football best bets suffered a tough 1-2 fate in Week 3, but we're ready to bounce back strong in Week 4. Check out our selections for Saturday, September 21 below. Good luck!
Will Rogers and the Washington Huskies are part of our best bets card for Week 4.
Will Rogers and the Washington Huskies are part of our best bets card for Week 4.
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2024 CFB Record: 5-4

Our college football best bets suffered a tough 1-2 fate in Week 3, but we're ready to bounce back strong in Week 4. Our selection on Indiana was an easy winner, but both TCU and West Virginia blew big leads late to ruin the day!

Check out our selections for Saturday, September 21 below. Good luck and enjoy the games folks!

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UL-Lafayette +3.5 over Tulane

9/21 - Noon PM EDT on ESPNU

I like this Tulane team quite a bit, but this is an awful spot for them. The Green Wave is hitting the road once again after putting up a great fight against Oklahoma last weekend. Jon Sumrall's squad also came within a whisker of upsetting No. 17 Kansas State the week before last.

You have to wonder just how much Tulane has left in the tank after those back-to-back slugfests against the big boys. On the flip side, this is a great spot for the Rajun Cajuns of Lafayette. Even though they've yet to face stiff competition, they're 2-0 and their fans will be rocking at home for this one!

Louisiana's rushing attack currently ranks 2nd in the country in yards per rush, as they average a robust 7.4 yards per carry. The Rajun Cajuns are led by a two-headed monster in the backfield with Zylan Perry and Elijah Davis. I think they'll do just fine against a Tulane defense that's giving up more than 5 yards per rush. Give me the home dog!

Jacksonville State -6.5 over So. Miss

9/21 - 3:00 PM EDT on ESPN+

Jax State will be hungry for their first win of the season after a disappointing 0-3 start. The Gamecocks have looked okay on offense, but their defense has looked lost so far in 2024. Something tells me that head coach Rich Rodriguez will have his guys supremely focused for this conference opener.

Tyler Huff has taken the starting QB job away from Logan Smothers, and the Jax State offense has looked much better ever since. Huff is a 6'1" senior who has a strong arm and comfortability in Rich Rod's offense. Look for Huff to hook up with Michael Pettway, who leads the team in receiving yardage, quite often in this one.

Southern Miss got a win in Week 2 against SE Louisiana, but they were blown out pretty badly in their other two outings against Kentucky and South Florida. The Golden Eagles' defense may be one of the worst units in college football. Let's lay the points with Jax State!

Washington -10 over Northwestern

9/21 - 7:00 PM EDT on FS1

I gobbled this number up over at BetMGM while the rest of the market has it priced at -10.5 or even -11.5. I get that the spot isn't too good for the Huskies after being upset by their archrival last week in the Apple Cup.

That being said, I don't think Northwestern has enough horses to compete in this game. Mike Wright has looked decent for the Wildcats at QB, but a lot of his stats were padded against Eastern Illinois last Saturday. I expect Wright to struggle against a pretty tough Washington defense on the road.

The Huskies are led by former Miss State standout Will Rogers. The 6'2" senior has done a fabulous job of commanding the Huskies offense, as he's already racked up over 800 passing yards and 6 touchdowns. Let's lay this moderate number with the home team!

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